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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are usually focused on practical aspects of the research design, 프라그마틱 플레이 like recruitment and consent in adherence, as well as the use of commonly available equipment.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however could cause issues with the trial design.

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The purpose of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are usually requested by practitioners and policymakers in order to inform their decisions. They also provide a useful way to identify the causality between the intervention and its effects. However, they should not be used to replace explanation studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention and its follow-up.

There is a positive increase in the number pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health science community is becoming more acquaint to the issue of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.